Matrixyl 3000
Palmitoyl peptide complex
Dermal repair signalling, collagen and matrix support
Matrixyl 3000 is a synergistic combination of two palmitoylated peptides — Palmitoyl Tetrapeptide-7 and Palmitoyl Tripeptide-1. The palmitoyl group makes the peptides lipophilic enough to penetrate the stratum corneum, where the peptide fragments act as messengers signalling dermal matrix synthesis.
Peptide chemistry in cosmetics is a mixed field. Many “peptide” products contain trace amounts of indeterminate peptide blends at concentrations that cannot reasonably be expected to do anything. Matrixyl 3000 is one of the better-characterised exceptions — the supplier publishes mechanism-of-action research, the dose-response relationship is documented, and formulation requirements are clearly specified.
We use it at 3% in our body serum, packaged in opaque, airless tubes to prevent the oxidative degradation that affects palmitoyl peptides over time.
The science
Sederma's published in vitro and ex vivo studies show stimulation of fibroblast collagen I, III, and fibronectin synthesis at 3-5% concentrations. The relevant clinical data is supplier-led but credible — improvements in skin firmness and wrinkle depth over 8-12 weeks of twice-daily application. The peptides act by mimicking matrix-degradation fragments, triggering a repair-signalling response.
